2018

• Structure of the 30 kDa HIV-1 RNA Dimerization Signal by a Hybrid Cryo-EM, NMR, and Molecular Dynamics Approach. (2018) Zhang, K, Keane, SC, Su, Z, Irobalieva, RN, Chen, M, Van, V, Sciandra, CA, Marchant, J, Heng, X, Schmid, MF, Case, DA, Ludtke, SJ, Summers, MF, & Chiu, W Structure 26(3):490-498 e493. PMCID5842133.
• Flagellum Couples Cell Shape to Motility in Trypanosoma brucei. (2018) Sun, SY, Kaelber, JT, Chen, M, Dong, X,  Nematbakhsh, Y, Shi, J,  Dougherty, M, Lim, CT, Schmid, MF, Chiu, W and He, CY  Proc Natl Acad Sci U S A 115(26): E5916-E5925. PMC6042131
• Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly. (2018) Su, Z, Wu, C, Shi, L, Luthra, P, Pintilie, GD, Johnson, B, Porter, JR, Ge, P, Chen, M, Liu, G, Frederick, TE, Binning, JM, Bowman, GR, Zhou, ZH, Basler, CF, Gross, ML, Leung, DW, Chiu, W, and Amarasinghe, GK Cell 172(5):966-978 e912. 
• The 3.5-Å CryoEM Structure of Nanodisc-Reconstituted Yeast Vacuolar ATPase V_o Proton Channel. (2018) Roh, SH, Stam, NJ, Hryc, CF, Couoh-Cardel, S, Pintilie, G, Chiu, W, and Wilkens, S Mol Cell 69(6):993-1004 e1003.
• Assessment of Structural Features in Cryo-EM Density Maps using SSE and Side Chain Z-Scores. (2018) Pintilie, G and Chiu, W J Struct Biol in press. PMCID in progress
• Novel Insect-Specific Eilat Virus-Based Chimeric Vaccine Candidates Provide Durable, Mono- and Multivalent, Single-Dose Protection against Lethal Alphavirus Challenge. (2018) Erasmus, JH, Seymour, RL, Kaelber, JT, Kim, DY, Leal, G, Sherman, MB, Frolov, I, Chiu, W, Weaver, SC, & Nasar, F J Virol 92(4). PMCID5790933.
• Visualizing Individual RuBisCO and Its Assembly into Carboxysomes in Marine Cyanobacteria by Cryo-Electron Tomography. (2018) Dai, W., Chen, M,  Myers, C, Ludtke, SJ, Pettitt, BM, King, JA, Schmid, MF and Chiu, W J Mol Biol. 430(21):4156-4167.
• Redox Engineering of Cytochrome c using DNA Nanostructure-Based Charged Encapsulation and Spatial Control. (2018) Ge, Z, Su, Z, Simmons, CR, Li, J, Jiang, S, Li, W, Yang, Y, Liu, Y, Chiu, W, Fan, C and Yan, H ACS Appl Mater Interfaces
• Neutralizing Antibodies Inhibit Chikungunya Virus Budding at the Plasma Membrane. (2018) Jin, J, Galaz-Montoya, JG, Sherman, MB, Sun, SY, Goldsmith, CS, O'Toole, ET,  Ackerman, L, Carlson, LA, Weaver, SC, Chiu W, and Simmons G Cell Host Microbe 24(3): 417-428 e415. PMC6137268.
• Structural Principles of Distinct Assemblies of the Human α4β2 Nicotinic Receptor. (2018) Walsh, RM, Roh, SH, Gharpure A, Morales-Perez CL, Teng J and Hibbs R Nature 557(7704):261-265. PMC6132059.
• New Software Tools in EMAN2 Inspired by EMDatabank Map Challenge. (2018) Bell, JM., Chen, M, Durmaz, T, Fluty AC and Ludtke, SJ J Struct Biol 204(2): 283-290. PMC6163079.
• Purification of AcrAB-TolC Multidrug Efflux Pump for Cryo-EM Analysis. (2018) Du, D, Wang, Z, Chiu, W, & Luisi, BF Methods Mol Biol 1700:71-81. 

2017

• Structural and Functional Impacts of ER Coactivator Sequential Recruitment. (2017) Yi, P, Wang, Z, Feng, Q, Chou, CK, Pintilie, GD, Shen, H, Foulds, CE, Fan, G, Serysheva, I, Ludtke, SJ, Schmid, MF, Hung, MC, Chiu, W, & O'Malley, BW, Mol Cell 67(5):733-743 e734. PMCID5657569.
• Influence of DNA sequence on the structure of minicircles under torsional stress. (2017) Wang, Q, Irobalieva, RN, Chiu, W, Schmid, MF, Fogg, JM, Zechiedrich, L, & Pettitt, BM Nucleic Acids Res 45(13):7633-7642. PMCID5737869.
• Programmable Supra-Assembly of a DNA Surface Adapter for Tunable Chiral Directional Self-Assembly of Gold Nanorods. (2017) Lan, X, Su, Z, Zhou, Y, Meyer, T, Ke, Y, Wang, Q, Chiu, W, Liu, N, Zou, S, Yan, H, & Liu, Y Angew Chem Int Ed Engl 56(46):14632-14636.
• Editorial overview: Cryo Electron Microscopy: Exciting advances in CryoEM Herald a new era in structural biology. (2017) Chiu, W & Downing, KH Curr Opin Struct Biol 46:iv-viii. PMCID5683930
• Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. (2017) Yang, K, Chang, JY, Cui, Z, Li, X, Meng, R, Duan, L, Thongchol, J, Jakana, J, Huwe, CM, Sacchettini, JC, & Zhang, J Nucleic Acids Res 45(18):10884-10894. PMCID
• A chikungunya fever vaccine utilizing an insect-specific virus platform. (2017) Erasmus, JH, Auguste, AJ, Kaelber, JT, Luo, H, Rossi, SL, Fenton, K, Leal, G, Kim, DY, Chiu, W, Wang, T, Frolov, I, Nasar, F, & Weaver, SC Nat Med 23(2):192-199. PMCID5296253.
• Subunit conformational variation within individual GroEL oligomers resolved by Cryo-EM. (2017) Roh, SH, Hryc, CF, Jeong, HH, Fei, X, Jakana, J, Lorimer, GH, & Chiu, W Proc Natl Acad Sci U S A 114(31):8259-8264. PMCID5547627.
• Convolutional neural networks for automated annotation of cellular cryo-electron tomograms. (2017) Chen, M, Dai, W, Sun, SY, Jonasch, D, He, CY, Schmid, MF, Chiu, W, & Ludtke, SJ Nature Methods 14(10):983-985. PMCID5623144.
• Electron Cryomicroscopy of Viruses at Near-Atomic Resolutions. (2017) Kaelber, JT, Hryc, CF, & Chiu, W Annu Rev Virol 10.1146/annurev-virology-101416-041921. PMCID
• The advent of structural biology in situ by single particle cryo-electron tomography (2017) Jesus G. Galaz-Montoya, Steven J. Ludtke Biophys Rep. doi:10.1007/s41048-017-0040-0
• Bridging the Gap Between Safety and Immunogenicity: A Chikungunya Fever Vaccine Utilizing an Insect-Specific Virus Platform. (2017) Erasmus, J, Auguste, A, Kaelber, J, Luo, H, Rossi, S, Fenton, K, Leal, G, Kim, D, Chiu, W, Wang, T, Frolov, I, Nasar, F, & Weaver, S Nat Med 23(2):192-199. PMCIDPMC5296253
• Visualizing Adsorption of Cyanophage P-SSP7 onto Marine Prochlorococcus. (2017) Murata, K, Zhang, Q, Gerardo Galaz-Montoya, J, Fu, C, Coleman, ML, Osburne, MS, Schmid, MF, Sullivan, MB, Chisholm, SW, & Chiu, W Sci Rep 7:44176. PMCID5345008.
• SuRVoS: Super-Region Volume Segmentation workbench. (2017) Luengo, I, Darrow, MC, Spink, MC, Sun, Y, Dai, W, He, CY, Chiu, W, Pridmore, T, Ashton, AW, Duke, EM, Basham, M, & French, AP J Struct Biol 198(1):43-53. PMCID5405849
• Accurate model annotation of a near-atomic resolution cryo-EM map. (2017) Hryc, CF, Chen, DH, Afonine, PV, Jakana, J, Wang, Z, Haase-Pettingell, C, Jiang, W, Adams, PD, King, JA, Schmid, MF, & Chiu, W Proc Natl Acad Sci U S A 114:3103-3108. PMCID 5373346.
• An allosteric transport mechanism for the AcrAB-1 TolC Multidrug Efflux Pump. (2017) Wang, Z, Fan, G, Hryc, CF, Blaza, JN, Serysheva, II, Schmid, MF, Chiu, W, Luisi, BF, & Du, D ELife. PMCID5404916

2016

• Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract. (2016) Shen, K, Calamini, B, Fauerbach, JA, Ma, B, Shahmoradian, SH, Serrano Lachapel, IL, Chiu, W, Lo, DC, & Frydman, J Elife 5. PMCID5135392.
• Fabrication of RNA 3D Nanoprisms for Loading and Protection of Small RNAs and Model Drugs. (2016) Emil F. Khisamutdinov, Daniel L. Jasinski, Hui Li, Kaiming Zhang, Wah Chiu, Peixuan Guo Advanced Materials DOI: 10.1002/adma.201603180 PMCID
• Asymmetric cryo-EM structure of the canonical Allolevivirus Qbeta reveals a single maturation protein and the genomic ssRNA in situ. (2016) Gorzelnik, KV, Cui, Z, Reed, CA, Jakana, J, Young, R, & Zhang, J Proc Natl Acad Sci U S A 113(41):11519-11524. PMID27671640
• Structural and Molecular Bases of Rod Photoreceptor Morphogenesis and Disease. (2016) Wensel, TG, Zhang, Z, Anastassov, IA, Gilliam, JC, He, F, Schmid, MF, & Robichaux, MA Prog. Retin. Eye Res. in press. PMID27352937
• Single-Particle Refinement and Variability Analysis in EMAN2.1. (2016) Ludtke, SJ Methods Enzymol 579:159-189. PMID27572727
• High resolution single particle refinement in EMAN2.1. (2016) Bell, JM, Chen, M, Baldwin, PR, & Ludtke, SJ Methods 100:25-34. PMIDPMC4848122
• De Novo Modeling in Cryo-EM Density Maps with Pathwalking. (2016) Chen, M, Baldwin, PR, Sludtke, SL, & Baker, ML J Struct Biol:in press. PMID27436409
• Tandem CAR T cells targeting HER2 and IL13Ralpha2 mitigate tumor antigen escape. (2016) Hegde, M, Mukherjee, M, Grada, Z, Pignata, A, Landi, D, Navai, SA, Wakefield, A, Fousek, K, Bielamowicz, K, Chow, KK, Brawley, VS, Byrd, TT, Krebs, S, Gottschalk, S, Wels, WS, Baker, ML, Dotti, G, Mamonkin, M, Brenner, MK, Orange, JS, & Ahmed, N J Clin Invest 126(8):3036-3052. PMCIDPMC4966331.
• Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions. (2016) Roh, SH, Kasembeli, MM, Galaz-Montoya, JG, Chiu, W, & Tweardy, DJ Biophys J 110(11):2377-2385. PMCID4906440.
• TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease. (2016) Zhao, X, Chen, XQ, Han, E, Hu, Y, Paik, P, Ding, Z, Overman, J, Lau, AL, Shahmoradian, SH, Chiu, W, Thompson, LM, Wu, C, & Mobley, WC Proc Natl Acad Sci U S A 113(38):E5655-5664. PMCID5035849
• Visualizing red blood cell sickling and the effects of inhibition of sphingosine kinase 1 using soft X-ray tomography. (2016) Darrow, MC, Zhang, Y, Cinquin, BP, Smith, EA, Boudreau, R, Rochat, RH, Schmid, MF, Xia, Y, Larabell, CA, & Chiu, W J Cell Sci 129(18):3511-3517. PMCID5047677
• Controllable Self-Assembly of RNA Tetrahedrons with Precise Shape and Size for Cancer Targeting. (2016) Li, H, Zhang, K, Pi, F, Guo, S, Shlyakhtenko, L, Chiu, W, Shu, D, & Guo, P Adv Mater 28(34):7501-7507. PMCID5059845
• Resolution and Probabilistic Models of Components in CryoEM Maps of Mature P22 Bacteriophage. (2016) Grigore Pintilie, Dong-Hua Chen, Cameron A. Haase-Pettingell, Jonathan A. King, Wah Chiu Biophysical Journal. Volume 110, Issue 4, 23 February 2016, Pages 827 - 839. PMCID4775875.
• The Electron Microscopy eXchange (EMX) initiative. (2016) Marabini R, Ludtke SJ, Murray SC, Chiu W, de la Rosa-Trevin JM, Patwardhan A, Heymann JB, & Carazo JM Journal of structural biology 194(2):156-163. PMCID in progress.
• Quantifying Variability of Manual Annotation in Cryo-Electron Tomograms. (2016) Hecksel CW, Darrow MC, Dai W, Galaz-Montoya JG, Chin JA, Mitchell PG, Chen S, Jakana J, Schmid MF, & Chiu W Microsc Microanal 10.1017/S1431927616000799:1-10. PMCID5111626.
• Designer nanoscale DNA assemblies programmed from the top down. (2016) Veneziano R, Ratanalert S, Zhang K, Zhang F, Yan H, Chiu W, & Bathe M Science 10.1126/ science.aaf4388. PMCID5111087.
• Tools for model building and optimization into near atomic resolution electron cryo-microscopy density maps. (2016) Dimaio F & Chiu W Methods in enzymology In press. PMCID5103630.
• EMDataBank unified data resource for 3DEM. (2016) Lawson CL, Patwardhan A, Baker ML, Hryc C, Garcia ES, Hudson BP, Lagerstedt I, Ludtke SJ, Pintilie G, Sala R, Westbrook JD, Berman HM, Kleywegt GJ, & Chiu W Nucleic acids research 44(D1):D396-403. PMCID4702818
• Alignment algorithms and per-particle CTF correction for single particle cryo-electron tomography. (2016) Galaz-Montoya,JG, Hecksel,CW, Baldwin,PR, Wang,E, Weaver,SC, Schmid,MF, Ludtke,SJ, & Chiu W Journal of structural biology 194(3):383-394. PMCID4846534.
• Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO. (2016) Roh SH, Kasembeli M, Galaz-Montoya JG, Trnka M, Lau WC, Burlingame A, Chiu W, & Tweardy DJ The Journal of biological chemistry 291(9):4732-4741. PMCID4813495.

2015

• Structural diversity of supercoiled DNA. (2015) Irobalieva, RN, Fogg, JM, Catanese, DJ, Sutthibutpong, T, Chen, M, Barker, AK, Ludtke, SJ, Harris, SA, Schmid, MF, Chiu, W, & Zechiedrich, L Nature communications 6:8440. PMCID4608029
• Erratum: Structural diversity of supercoiled DNA. (2015) Irobalieva, RN, Fogg, JM, Catanese, DJ, Sutthibutpong, T, Chen, M, Barker, AK, Ludtke, SJ, Harris, SA, Schmid, MF, Chiu, W, & Zechiedrich, L Nature communications 6:8440. PMID: 26511109
• Outcome of the First wwPDB Hybrid/Integrative Methods Task Force Workshop. (2015) Sali, A, Berman, HM, Schwede, T, Trewhella, J, Kleywegt, G, Burley, SK, Markley, J, Nakamura, H, Adams, P, Bonvin, AM, Chiu, W, Peraro, MD, Di Maio, F, Ferrin, TE, Grunewald, K, Gutmanas, A, Henderson, R, Hummer, G, Iwasaki, K, Johnson, G, Lawson, CL, Meiler, J, Marti-Renom, MA, Montelione, GT, Nilges, M, Nussinov, R, Patwardhan, A, Rappsilber, J, Read, RJ, Saibil, H, Schroder, GF, Schwieters, CD, Seidel, CA, Svergun, D, Topf, M, Ulrich, EL, Velankar, S, & Westbrook, JD Structure 23(7):1156-1167.
• Gating machinery of InsP3R channels revealed by electron cryomicroscopy. (2015) Fan, G, Baker, ML, Wang, Z, Baker, MR, Sinyagovskiy, PA, Chiu, W, Ludtke, SJ, & Serysheva, II Nature 527(7578):336-341.
• Bolaamphiphiles as carriers for siRNA delivery: From chemical syntheses to practical applications. (2015) Gupta K, Afonin KA, Viard M, Herrero V, Kasprzak W, Kagiampakis I, Kim T, Koyfman AY, Puri A, Stepler M, Sappe A, KewalRamani VN, Grinberg S, Linder C, Heldman E, Blumenthal R, Shapiro BA J Control Release. 2015 Jul 4;213:142-151. doi: 10.1016/j.jconrel.2015.06.041.
• Dimeric Organization of Blood Coagulation Factor VIII bound to Lipid Nanotubes. (2015) Dalm D, Galaz-Montoya JG, Miller JL, Grushin K, Villalobos A, Koyfman AY, Schmid MF, Stoilova-McPhie S. Sci Rep. 2015 Jun 17;5:11212. doi: 10.1038/srep11212.
• Domain organization and conformational plasticity of the G protein effector, PDE6. (2015) Zhang Z, He F, Constantine R, Baker ML, Baehr W, Schmid MF, Wensel TG, Agosto MA. J Biol Chem. Jul 10;290(28):17131-2. doi: 10.1074/jbc.A115.647636.
• Erratum: Domain organization and conformational plasticity of the G protein effector, PDE6. (2015) Zhang Z, He F, Constantine R, Baker ML, Baehr W, Schmid MF, Wensel TG, Agosto MA. J Biol Chem. May 15;290(20):12833-43. doi: 10.1074/jbc.M115.647636.
• Single particle tomography in EMAN2. (2015) Galaz-Montoya JG, Flanagan J, Schmid MF, Ludtke SJ. J Struct Biol. 2015 Jun;190(3):279-90. doi: 10.1016/j.jsb.2015.04.016. Epub 2015 May 5
• Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin. (2015) Tan, Z, Dai, W, van Erp, TG, Overman, J, Demuro, A, Digman, MA, Hatami, A, Albay, R, Sontag, EM, Potkin, KT, Ling, S, Macciardi, F, Bunney, WE, Long, JD, Paulsen, JS, Ringman, JM, Parker, I, Glabe, C, Thompson, LM, Chiu, W, & Potkin, SG Molecular psychiatry 10.1038/mp.2015.81. PMCID in progress
• Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography. (2015) Darrow, MC, Sergeeva, OA, Isas, JM, Galaz-Montoya, JG, King, JA, Langen, R, Schmid, MF, & Chiu, W The Journal of biological chemistry 290(28):17451-17461. PMCID4498080.
• CTF Challenge: Result summary (2015) Marabini, R, Carragher, B, Chen, S, Chen, J, Cheng, A, Downing, KH, Frank, J, Grassucci, RA, Bernard Heymann, J, Jiang, W, Jonic, S, Liao, HY, Ludtke, SJ, Patwari, S, Piotrowski, AL, Quintana, A, Sorzano, CO, Stahlberg, H, Vargas, J, Voss, NR, Chiu, W, & Carazo, JM Journal of structural biology 10.1016/j.jsb.2015.04.003.
• An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions. (2015) Leung, DW, Borek, D, Luthra, P, Binning, JM, Anantpadma, M, Liu, G, Harvey, IB, Su, Z, Endlich-Frazier, A, Pan, J, Shabman, RS, Chiu, W, Davey, RA, Otwinowski, Z, Basler, CF, & Amarasinghe, GK Cell reports 11(3):376-389.
• Structure of a biologically active estrogen receptor-coactivator complex on DNA. (2015) Yi, P, Wang, Z, Feng, Q, Pintilie, GD, Foulds, CE, Lanz, RB, Ludtke, SJ, Schmid, MF, Chiu, W, & O'Malley, BW Molecular cell 57(6):1047-1058.
• A newly isolated reovirus has the simplest genomic and structural organization of any reovirus.(2015) Auguste, AJ, Kaelber, JT, Fokam, EB, Guzman, H, Carrington, CV, Erasmus, JH, Kamgang, B, Popov, VL, Jakana, J, Liu, X, Wood, TG, Widen, SG, Vasilakis, N, Tesh, RB, Chiu, W, & Weaver, SC .,Journal of virology 89(1):676-687.
• Lemon-shaped halo archaeal virus His1 with uniform tail but variable capsid structure. (2015) Hong, C, Pietila, MK, Fu, CJ, Schmid, MF, Bamford, DH, & Chiu, W., Proceedings of the National Academy of Sciences of the United States of America 112(8):2449-2454.